Content: Safety brief: Bruton’s tyrosine kinase (BTK) inhibitors and the risk of serious hepatotoxicity; Notice of authorization with conditions: Lyvdelzi (seladelpar)

The list of new safety and effectiveness reviews has been updated and now includes safety reviews initiated between October 1 and 31, 2025. The next update is scheduled for January 2026.

The data presented in the Canada Vigilance Adverse Reaction Online Database has been updated and now includes information received by Health Canada up to August 31, 2025. The next update of data is scheduled for early January, 2026.

Content: Product monograph update: Braftovi (encorafenib); Notice of authorization with conditions: Jaypirca (pirtobrutinib); Notice of authorization with conditions: Leqembi (lecanemab)

The data presented in the Canada Vigilance Adverse Reaction Online Database has been updated and now includes information received by Health Canada up to July 31, 2025. The next update of data is scheduled for early December, 2025.

The list of new safety and effectiveness reviews has been updated and now includes safety reviews initiated between September 1 and 30, 2025. The next update is scheduled for December 2025.